Marketed supplement boosts weight loss and increases muscle mass in overweight men and women
- Lizette Rios
- Dec 5, 2017
- 3 min read

Introduction
There are many products that claim to reduce fat and body weight, but are rarely tested using the scientific method.
This study looked at the safety and ability of this supplement to see if it performs as it claims.
It contains various ingredients:
Capsaicin
Caffeine
Citrus aurantium
Garlic
Raspberry ketone
Ginger
The product is known as Prograde MetabolismTM (METABO).

Methods
This was a double-blind study- meaning individuals did not know whether they were consuming the placebo or the supplement.
The placebo is a harmless pill that has no physiological effect on the individual.
70 overweight individuals were selected and randomly placed in the METABO treated group or the placebo group for 8 weeks.
The two groups took the supplement (recommended daily dosage) or placebo, were on a calorie restricted diet (500 kcal deficit, details below) and exercised.

Scientists analyzed body composition, heart rate, blood pressure and inflammation.
Results
Of the 70 individuals that started the study, only 45 completed it.
METABO: 27 total; men (12) and women (15)
Placebo: 18 total; men (7) and women (11)
They found that the METABO supplement did the following:
Reduced body weight
Increased muscle mass
Decreased waist size
Decreased hip size
Increased Leptin – suppresses appetite
Increased energy levels
Safety of the product was established
Conclusion
METABO is safe and effective for weight loss, gaining muscle, increasing energy and suppressing appetite.
More studies are needed to identify how these ingredients work together to produce these beneficial effects.
Reflection
Supplement seems to be effective.
What is bothersome about this study was the small placebo group, it can affect the statistics a bit.
But there were a good number of individuals within the METABO group so the information seems valid.
I think it is necessary to repeat this study to identify the mechanism of action of the ingredients, as well as increasing sample size to account for potential drop-outs.
*Before consuming supplements, consult with a physician, individuals can be affected differently.
Sources
Image courtesy of:
“Do Weight Loss Pills Actually Work?” Healthy Diet Advisor, 7 Sept. 2017, www.healthydietadvisor.com/weight-loss/pills/do-weight-loss-pills-actually-work/.
Scientific Article courtesy of:
Lopez, Hector L, et al. Eight weeks of supplementation with a multi-Ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. Journal of the International Society of Sports Nutrition, BioMed Central, 19 Apr. 2013, jissn.biomedcentral.com/articles/10.1186/1550-2783-10-22.
Morimoto C, Satoh Y, Hara M, Inoue S, Tsujita T, Okuda H: Anti-obese action of raspberry ketone. Life Sci 2005, 77:194–204.
Park KS: Raspberry ketone increases both lipolysis and fatty acid oxidation in 3 T3-L1 adipocytes. Planta Med 2010, 76:1654–1658.
Diepvens K, Westerterp KR, Westerterp-Plantenga MS: Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol 2007, 292:R77–R85.
Josse AR, Sherriffs SS, Holwerda AM, Andrews R, Staples AW, Phillips SM: Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise. Nutr Metab 2010, 7:65.
Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M: Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 2012, 95:845–850.
Bloomer R, Canale R, Shastri S, Suvarnapathki S: Effect of oral intake of caspaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adult: a randomized, placebo, controlled, double- blind, cross-over study. Lipids Health Dis 2010, 9:72.
Okamoto M, Irii H, Tahara Y, Ishii H, Hirao A, Udagawa H, Hiramoto M, Yasuda K, Takanishi A, Shibata S, Shimizu I: Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet. J Med Chem 2011, 54:6295–6304.
Isa Y, Miyakawa Y, Yanagisawa M, Goto T, Kang MS, Kawada T, Morimitsu Y, Kubota K, Tsuda T: 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3 T3-L1 adipocytes.Biochem Biophys Res Commun 2008, 373:429–434.
Ban JO, Lee DH, Kim EJ, Kang JW, Kim MS, Cho MC, Jeong HS,
Kim JW, Yang Y, Hong JT, Yoon do Y: Antiobesity effects of a sulfur compound thiacremonone mediated via down-regulation of serum triglyceride and glucose levels and lipid accumulation in the liver of db/db mice. Phytother Res 2012, 26:1265–1271.
Ernsberger P, Johnson JL, Rosenthal T, Mirelman D, Koletsky RJ: Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome. Am J Hypertens 2007, 20:866–874.
Stohs SJ, Preuss HG, Shara M: A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. Int J Med Sci 2012, 9:527–538.
Комментарии