Nitric Oxide supplement can help patients at risk of high blood pressure
- Lizette Rios
- Jan 5, 2018
- 4 min read

Introduction
This study looked at the effects of patients at risk of hypertension (prehypertension) treated with Nitric Oxide supplement.

Prehypertension – is being at risk for hypertension
Hypertension – high blood pressure (can be due to atherosclerosis – explained at cardiovascular disease below). Blood forcefully flows through blood vessels, it can stress the heart and damage vessels. This increases the chances of stroke, heart attack, kidney problems and death.
Cardiovascular disease – Heart disease, usually in the form of atherosclerosis.
Atherosclerosis – is plaque (fat, cholesterol, calcium and other substances) that accumulates, solidifies and surrounds the walls of blood vessels. Due to the narrowing of the blood vessel, this limits blood flow and can cause high blood pressure.

*Courtesy of the CDC – High blood pressure
mmHg = millimeter of mercury; scale used to measure pressure in your blood vessels
systolic = is the first number, it measures pressure in blood vessels when the heart beats
diastolic = is the second number, it measures pressure in blood vessels when the heart rests between beats
Example: 120/80 mmHg
Methods

*Supplement name: Neo40 Daily®
It is in the form of a quick-dissolving lozenge.
A placebo is a harmless substance that has no physiological effect on the individual, it is used to compare results with the treatment group.
Scientists analyzed the following pre-treatment and post-treatment (before supplementation and after supplementation):
1. heart rate
2. blood pressure
3. distance from 6-minute walk test (to test oxygen intake while exercising and endurance)
4. Two quality of life assessment questionnaire’s
Results
They found that Neo40 Daily® treatment for prehypertensive patients did the following:
1. Decreased blood pressure compared to pretreatment:
12mm Hg reduction in systolic and 6 mm Hg reduction in diastolic pressures.
Average: 126/78 mm Hg
Systolic = prehypertensive
Diastolic = normal
2. Increased 6-minute walk test compared to pretreatment:
55-meter improvement
3. Improved scores for both quality of life assessment questionnaires, pre-treatment compared to post-treatment.
4. No changes:
Heart rate
They found that the placebo for prehypertensive patients did the following:
1. No changes in blood pressure compared to pretreatment
2. No changes in 6-minute walk test compared to pretreatment
3. Worsening of scores for both quality of life assessment questionnaire’s
Conclusion
Supplementing with Neo40 Daily® decreased blood pressure, increased walking distance, and improved scores for quality of life assessment questionnaires.
Reflection
This study had a small number of patients and was for a short duration (30 days). Perhaps supplementing with Neo40 Daily® for a longer time period may improve blood pressure.
Within 30 days blood pressure did decrease, but average systolic was within the prehypertensive range and diastolic was within normal range (within Results).
The article did not specify the supplement that they used, which I thought was a bit strange. I did some digging through references and was able to identify the treatment used.
Neo40 Daily® seems to be effective in reducing the risk of developing high blood pressure. If you have already been diagnosed with hypertension, this supplement may be helpful, but keep in mind that the patients in this study were “at risk” of developing hypertension and were not diagnosed with hypertension.
Currently the only treatment for prehypertension is diet and lifestyle changes.
Amazon has the supplement available for purchasing. There are also other websites/places it can be purchased as well.

*Before consuming supplements, consult with a physician, individuals can be affected differently.
Sources
Scientific Article courtesy of:
Biswas, Olivia S., et al. “Effects of an Oral Nitric Oxide Supplement on Functional Capacity and Blood Pressure in Adults With Prehypertension.” Journal of Cardiovascular Pharmacology and Therapeutics, vol. 20, no. 1, 2014, pp. 52–58., doi:10.1177/1074248414539563.
Image courtesy of:
Fisher, MD Naomi D. L. “High blood pressure: Why me?” Harvard Health Blog, 24 May 2016, www.health.harvard.edu/blog/high-blood-pressure-why-me-201605029288.
Image courtesy of:
“Neo40 Daily - Nitric Oxide Booster Nitric Oxide Test Strip Bundle - May Help Promote Healthy Blood Pressure and Cardiovascular Health - 30 Tablets with 25 Strips: Health & Personal Care.” Amazon.com: Neo40 Daily - Nitric Oxide Booster Nitric Oxide Test Strip Bundle - May Help Promote Healthy Blood Pressure and Cardiovascular Health - 30 Tablets with 25 Strips: Health & Personal Care, www.amazon.com/Neo40-Daily-Booster-Pressure-Cardiovascular/dp/B072Y8WDRD/ref=sr_1_3_sspa?s=hpc&ie=UTF8&qid=1515112171&sr=1-3-spons&keywords=neo40&psc=1.
Image courtesy of:
Robert, Reviewer Jeni. “Jeni Robert.” Genuine Health Reviews, 5 Dec. 2017, genuinehealthreviews.com/high-blood-pressure/.
Table courtesy of:
“High Blood Pressure.” Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, 17 Oct. 2017, www.cdc.gov/bloodpressure/measure.htm.
Kelm M. Nitric oxide metabolism and breakdown. Biochim Bio- phys Acta. 1999;1411(2-3):273-289.
Lundberg JO, Weitzberg E, Gladwin MT. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008;7(2):156-167.
Koshland DE Jr. The molecule of the year. Science. 1992; 258(5090):1861.
Zand J, Lanza F, Garg HK, Bryan NS. All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans. Nutr Res. 2011;31(4):262-269.
Stokes KY, Dugas TR, Tang Y, Garg H, Guidry E, Bryan NS. Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2009;296(5):H1281-H1288.
Bryan NS, Calvert JW, Elrod JW, Gundewar S, Ji SY, Lefer DJ. Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury. Proc Natl Acad Sci. 2007;104(48): 19144-19149.
Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the joint national committee on prevention, detection, evaluation, and treat- ment of high blood pressure. Hypertension. 2003;42(6):1206-1252.
Ware J, Kosinski M, Keller S. SF-36 physical and mental health summary scales: a user’s manual. Boston, MA: Health Assess- ment Lab. 1994.
Bryan NS. Application of nitric oxide in drug discovery and development. Expert Opin Drug Discov. 2011;6(11):1139-1154. 10. Doel JJ, Benjamin N, Hector MP, Rogers M, Allaker RP. Evaluation of bacterial nitrate reduction in the human oral cavity. Eur J Oral Sci. 2005;113(1):14-19.
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